Validated Performance
>800
Experimental tests across multiple CAR architectures
0.08%
Detection sensitivity for CAR-positive cells
Ultra-low
Nonspecific background signal
Reproducible
Performance across independent batches
Overview
The SCOPE BCMA CAR Detection Reagent enables precise identification and quantification of BCMA-directed CAR-expressing cells using flow cytometry.
- Antigen-based detection targeting the CAR binding domain
- Compatible across diverse BCMA CAR construct designs
- Optimized for low background staining and strong signal intensity
Site-specific enzymatic labeling supports highly consistent reagent performance across production batches. Validated across BCMA CAR designs incorporating CD8α and IgG-derived hinge regions, enabling reliable detection across commonly used construct formats.
Key Benefits
High Specificity & Low Background
Designed for robust discrimination between CAR-positive and CAR-negative cells with minimal nonspecific binding.
Batch-to-Batch Reproducibility
Manufacturing processes optimized for consistent performance across independently produced reagent lots.
Workflow Integration
Compatible with standard flow cytometry staining protocols and standard instrument configurations.
Cross-CAR Compatibility
Validated across BCMA CAR architectures incorporating CD8α and IgG-derived hinge regions.
Scientific Validation
Detection Sensitivity
Serial dilution experiments demonstrate reliable detection of rare CAR-positive populations down to 0.08%, with strong agreement between expected and measured values.
Detection of CAR-positive cells across serial dilution with consistent quantification at low frequencies.
Low Background Binding
The engineered antigen-based design minimizes nonspecific interactions, enabling clear separation between CAR-positive and CAR-negative populations with near-zero background signal.
Reproducible Performance
Independent reagent batches demonstrate highly consistent signal intensity and CAR-positive frequencies, supporting reliable quantitative analysis across experiments.
Why SCOPE Detection Reagents
- Antigen-based detection for highly specific CAR recognition
- Reduced background compared to conventional Fc-based reagents
- Consistent performance across reagent batches
- Compatible with standard flow cytometry workflows
- Designed for reproducible and comparable results
Technical Highlights
Target
BCMA-directed CAR constructs
Application
Flow cytometry
Formats
PE, Biotin
Kit Size
30 tests
Use
Research use only
Documents
Research Use Only (RUO): This product is intended for research use only and is not for use in diagnostic or therapeutic procedures.